Dried formulations of nanoparticle-coated capsules

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/50 (2006.01) A61J 3/00 (2006.01) A61J 3/02 (2006.01) A61K 9/51 (2006.01) A61K 9/52 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2608226

A method of producing a dried formulation for an active substance such as a drug compound is described. The method involves dispersing a discontinuous phase (e.g. an oil-based or lipidic medium) comprising the active substance into a continuous phase (e.g. water) so as to form a two- phase liquid system comprising droplets of said discontinuous phase, allowing nanoparticles to congregate at the phase interface at the surface of the droplets such that at least one layer of nanoparticles coat the droplets and thereby provide sufficient structural integrity to the droplets to enable the subsequent removal of the continuous phase, and thereafter removing the continuous phase from the nanoparticle-coated droplets to produce a dried formulation.

La présente invention concerne un procédé de production d'une composition déshydratée pour une substance active, notamment un composé de médicament. Le procédé consiste à disperser une phase discontinue (un milieu à base d'huile ou lipidique par exemple) comprenant la substance active en une phase continue (de l'eau par exemple) de façon à former un système liquide à deux phases comprenant des gouttelettes de ladite phase discontinue, à permettre aux nanoparticules de s'agglomérer à l'interface de phases à la surface des gouttelettes, de sorte qu'au moins une couche de nanoparticules enrobe les gouttelettes et offre par là une intégrité structurelle suffisante aux gouttelettes pour permettre la séparation ultérieure de la phase continue, et à séparer ensuite la phase continue des gouttelettes enrobées de nanoparticules afin de produire une composition déshydratée.

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