Use of an insulin sensitiser for the treatment of type 2...

Details Use of an insulin sensitiser for the treatment of type 2... Use of an insulin sensitiser for the treatment of type 2...

A - Human Necessities

61

K

A61K 31/4439 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2350425

A method for the treatment of Type 2 diabetes mellitus and conditions associated with diabetes mellitus, which method comprises the administration to a human or non-human mammal in need thereof, of an effective non-toxic amount of an insulin sensitiser so as to provide a plasma concentration of the insulin sensitiser of at least a threshold level (the "Threshold Plasma Concentration") from within the range of effective plasma levels of the insulin sensitiser, compositions for use in such method and methodology for determining plasma concentrations of active agent use in such methods.

Cette invention a trait à une méthode de traitement du diabète sucré du type 2 et d'états pathologiques associés au diabète sucré. Cette méthode consiste à administrer à un mammifère, humain ou non, une quantité efficace non toxique d'un agent de sensibilisation à l'insuline de manière à assurer une concentration plasmatique de cet agent de sensibilisation d'au moins un taux de seuil (concentration plasmatique de seuil) dans la gamme des taux plasmatiques efficaces de l'agent de sensibilisation à l'insuline. L'invention porte également sur des compositions utilisables dans le cadre de cette méthode ainsi que sur des techniques permettant de déterminer des concentrations plasmatiques de l'agent efficace utilisé dans cette méthode.

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