Peptides that bind to atherosclerotic lesions

Details Peptides that bind to atherosclerotic lesions Peptides that bind to atherosclerotic lesions

C - Chemistry, Metallurgy

07

K

C07K 4/00 (2006.01) A61K 38/00 (2006.01) A61K 38/03 (2006.01) A61K 38/08 (2006.01) C07C 233/00 (2006.01) C07H 21/00 (2006.01) C07K 7/06 (2006.01) C07K 19/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2455336

The present invention provides peptides that selectively bind to mammalian atherosclerotic lesions. The present invention also provides methods for in vivo identification of peptides capable of binding to biomolecules as well as methods for identifying the targets of such binding moieties. Methods to diagnose or treat pathologic conditions that involve atherosclerotic lesions are also provided by the invention that involve administering to a mammal a peptide attached to a reporter molecule or a therapeutic agent, respectively.

L'invention concerne des peptides se liant sélectivement avec les lésions athéroscléreuses chez le mammifère, ainsi que des procédés d'identification in vivo de peptides capables de liaison avec des biomolécules, et des procédés d'identification de cibles pour ces fractions de liaison. L'invention concerne par ailleurs des procédés pour le diagnostic ou le traitement d'états pathologiques qui occasionnent les lésions susmentionnées, consistant à administrer aux mammifères affectés un peptide lié à une molécule rapportrice ou à un agent thérapeutique, respectivement.

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