Single nucleotide polymorphisms (snp) and association with...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) G06F 19/20 (2011.01) C40B 30/04 (2006.01)

Patent

CA 2721651

This application discloses methods, systems and kits for correlating the presence or absence of certain nucleic acid sequences within a population with the ability to create immune tolerance in that same population. Tolerance can be induced by solo or repeated administration of antigen, including soluble antigens administered either intravenously or sublingually. This application also discloses methods for detecting variants. In addition the application addresses the use or avoidance of non steroidal anti inflammatory drugs in therapy.

Linvention concerne des procédés, des systèmes et des nécessaires pour corréler la présence ou labsence de certaines séquences dacides nucléiques dans une population avec la capacité à créer une tolérance immunitaire dans cette même population. La tolérance peut être induite par une administration seule ou répétée dantigène, comprenant des antigènes solubles administrés soit par voie intraveineuse, soit par voie sublinguale. La présente invention concerne également des procédés de détection de variantes. En plus, linvention examine lutilisation ou le fait déviter des médicaments anti-inflammatoires non stéroïdiens en thérapie.

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