Neurotrophic factor secretion promoters

A - Human Necessities – 61 – K

Patent

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Details

A61K 45/00 (2006.01) A61K 31/00 (2006.01) A61K 31/15 (2006.01) A61K 31/16 (2006.01) A61K 31/198 (2006.01) A61K 31/21 (2006.01) A61K 31/34 (2006.01) A61K 31/5377 (2006.01) A61K 31/655 (2006.01)

Patent

CA 2319387

Neurotrophic factor secretion promoters, in particular, brain-derived neurotrophic factor (BDNF) secretion promoters containing as the active ingredient NO donors. These drugs promote the secretion of neurotrophic factors from mammalian central nerve cells. Thus, these drugs, i.e., NO donors are expected as being applicable to the treatment of diseases (for example, nerve degeneration-associated diseases) against which neurotrophic factors are efficacious and exerting beneficial effects thereon. Also, a novel drug therapy for nerve degeneration-associated diseases is provided.

L'invention concerne des promoteurs de sécrétion du facteur neurotrophique, en particulier, des promoteurs de sécrétion du facteur neurotrophique dérivé du cerveau (BDNF) contenant comme principe actif des donneurs de NO. Ces médicaments favorisent la sécrétion de facteurs neurotrophiques par les cellules du système nerveux central mammifère. Ainsi, on attend de ces médicaments, à savoir les donneurs de NO, qu'il soient applicables au traitement de maladies (par exemple, de maladies associées à une dégénérescence nerveuse) contre lesquelles des facteurs neurotrophiques sont efficaces, et qu'ils aient des effets bénéfiques sur celles-ci. En outre, l'invention concerne une nouvelle pharmacothérapie contre des maladies associées à une dégénérescence nerveuse.

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