A method of modulating b cell functioning

Details A method of modulating b cell functioning A method of modulating b cell functioning

A - Human Necessities

61

K

A61K 31/167 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/47 (2006.01) A61P 3/10 (2006.01) A61P 7/06 (2006.01) A61P 17/06 (2006.01) A61P 25/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2587407

The present invention relates generally to a method of modulating cellular functioning. More particularly, the present invention relates to a method of modulating B cell functioning, for example B cell proliferation, utilising an IDO- mediated tryptophan metabolite as herein defined (particular examples of such IDO-mediated tryptophan metabolites include 3-hydroxykynurenic acid, 3- hydroxyanthranilic acid, picolinic acid, quinolinic acid and tranilast). The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate B cell functioning such as antibody production, autoimmune conditions and B cell proliferation and neoplasias. In a related aspect, the present invention is directed to a method of therapeutically and/or prophylactically treating rheumatoid arthritis via the administration of the above-mentioned compounds.

La présente invention concerne de façon générale un procédé de modulation du fonctionnement cellulaire. Plus particulièrement, la présente invention concerne un procédé de modulation du fonctionnement des cellules B, par exemple de la prolifération des cellules B, en utilisant un métabolite du tryptophane de la voie IDO tel que défini ici (les exemples particuliers de tels métabolites du tryptophane de la voie IDO comprennent l'acide 3-hydroxykynurénique, l'acide 3-hydroxyanthranilique, l'acide picolinique, l'acide quinolinique et le Tranilast). Le procédé de la présente invention est utile, entre autres, dans le traitement et/ou la prophylaxie d'affections caractérisées par un fonctionnement aberrant, non voulu ou autrement inapproprié des cellules B tel que la production d'anticorps, des affections auto-immunes et la prolifération des cellules B et de la néoplasie. Dans un aspect connexe, la présente invention concerne un procédé de traitement thérapeutique et/ou prophylactique de la polyarthrite rhumatoïde via l'administration des composés susmentionnés.

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