Use of lactobacillus reuteri to inhibit cryptosporidiosis in...

A - Human Necessities – 61 – K

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A61K 35/74 (2006.01) A23C 9/152 (2006.01) A23L 1/03 (2006.01)

Patent

CA 2213434

Cryptosporidium parvum (the cause of cryptosporidiosis) has become one of the most common enteropathogens causing diarrhea worldwide. Symptoms associated with cryptosporidiosis are very debilitating especially in the immunocompromised subject (e.g., AIDS patient). Clinical features include severe, chronic diarrhea, abdominal cramps, fatigue, weight loss, etc. which lead to increased health care costs and increased mortality. There is disclosed herein a method of inhibiting the severity of Cryptosporidium parvum infection by enterally administering a therapeutically effective amount of Lactobacillus reuteri.

Le Cryptosporidium parvum (à l'origine de la cryptosporidiose) est devenu un des entéropathogènes les plus communs, provoquant des diarrhées partout dans le monde. Les symptômes associés à la cryptosporidiose sont très débilitants, notamment chez les sujets immunodéprimés (tels que les patients atteints du SIDA). Les manifestations cliniques sont des diarrhées sévères, chroniques, des crampes abdominales, la fatigue, la perte de poids, etc., qui entraînent une hausse de la mortalité ainsi qu'une hausse des coûts relatifs aux soins médicaux et de santé. L'invention se rapporte à un procédé d'inhibition de la sévérité des infections dues à Cryptosporidium parvum qui consiste à administrer par voie entérale une quantité thérapeutiquement efficace de Lactobacillus reuteri.

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