C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 1/10 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2405728
This invention relates to novel antiproliferative and anti secrectory peptides that are inhibitory to vasoactive intestinal peptide receptor and are useful in the treatment of cancer. The invention particularly relates to the synthesis of lipid-peptide conjugates containing fatty acids of different sizes, which inhibits the binding of VIP to its receptors. The invention encompasses methods for generation of these peptides, composition containing these peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
L'invention porte sur de nouveaux peptides antiprolifération et antisécrétoires inhibiteurs du récepteur des peptides intestinaux vasoactifs (VIP) et utilisables pour le traitement du cancer, et en particulier sur la synthèse de conjugués lipides-peptides contenant des acides gras de différentes tailles, et qui inhibent la fixation des VIPs à leurs récepteurs. L'invention porte en outre sur les procédés d'élaboration de ces peptides, sur des préparations les contenant et sur des applications pharmacologiques de ces peptides spécialement destinées au traitement et à la prévention du cancer.
Burman Anand C.
Jaggi Manu
Mukherjee Rama
Prasad Sudhanand
Sharma Rajan
Dabur Research Foundation
Marks & Clerk
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