Treatment of depression and pharmaceutical preparations...

Details Treatment of depression and pharmaceutical preparations... Treatment of depression and pharmaceutical preparations...

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 31/135 (2006.01) A61K 31/15 (2006.01) A61K 31/343 (2006.01) A61K 31/4525 (2006.01) A61K 31/496 (2006.01) A61K 31/5375 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2329665

It has been found that the treatment of depression using known SRIs and NRIs may be improved by the administration therewith of folic acid or a precursor which produces folate in the patient. The daily dose of NRI or SRI is as prescribed for treatment of depression in the usual way. The daily dose of the folic acid precursor should be such as to provide a folate dosage of 300-5000 micrograms/day.

Il a été découvert qu'il est possible d'améliorer le traitement habituel de la dépression par des inhibiteurs de la réabsorption de la sérotonine (SRI) et des inhibiteurs de la réabsorption de la noradrénaline (NRI) connus en administrant, conjointement à ceux-ci, de l'acide folique ou un précurseur produisant du folate à l'intérieur du patient. La dose journalière de NRI ou de SRI est celle qui est normalement prescrite pour le traitement de la dépression. La dose journalière de précurseur d'acide folique devrait être calculée pour correspondre à une dose de folate de 300 à 5000 microgrammes par jour.

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