C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/04 (2006.01) A61K 31/34 (2006.01) A61K 31/36 (2006.01) A61P 31/12 (2006.01)
Patent
CA 2386850
The present invention relates to novel bis-tetrahydrofuran benzodioxolyl sulfonamide compounds which are sur-prisingly effective protease inhibitors. The invention also relates to pharmaceutical compositions, methods of inhibiting retrovirus proteases, in particular multidrug resistant retrovirus proteases, methods of treating or combating infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication.
La présente invention concerne des composés bis-tétrahydrofuran benzodioxolyl sulfonamide qui sont des inhibiteurs de protéase étonnamment efficaces. Elle concerne aussi des compositions pharmaceutiques, des méthodes d'inhibition de protéases de rétrovirus, en particulier des protéases de rétrovirus résistantes aux multithérapies, des méthodes de traitement ou de combat d'infection ou de maladie associée à une infection rétrovirale chez un mammifère, et des méthodes d'inhibition de réplication virale.
Eissenstat Michael
Erickson John W.
Wang Guangyang
Wigerinck Piet Tom Bert Paul
Gowling Lafleur Henderson Llp
The Government Of The United States Of America Represented By Th Department Of Health And Human Services; National Institutes Of
Tibotec Pharmaceuticals Ltd.
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