Human dnase i variants

Details Human dnase i variants Human dnase i variants

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 38/46 (2006.01) C12N 9/16 (2006.01) C12N 9/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2211413

The present invention relates to amino acid sequence variants of human DNase I that have reduced binding affinity for actin. The invention provides nucleic acid sequences encoding such actin-resistant variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of actin-resistant variants of human DNase I.

L'invention concerne des variantes de séquences d'acides aminés de DNase I humaine présentant une affinité de liaison réduite vis-à-vis de l'actine. L'invention concerne des séquences d'acides nucléiques codant lesdites variantes résistantes à l'actine, permettant ainsi la production de ces variantes en quantités suffisantes pour une utilisation clinique. L'invention concerne également des compositions pharmaceutiques et des utilisations thérapeutiques de variantes de DNase I humaine résistantes à l'actine.

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