Imidazopyridine derivatives as sirtuin modulating agents

Details Imidazopyridine derivatives as sirtuin modulating agents Imidazopyridine derivatives as sirtuin modulating agents

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61P 3/00 (2006.01) A61P 7/00 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 27/00 (2006.01) A61P 39/00 (2006.01)

Patent

CA 2618368

Provided herein are imidazopyridine derivatives of formulas ((XIV), (XV),(XVI) and (XVII) which are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

La présente invention se rapporte à des dérivés d~imidazopyridine des formules (XIV), (XV), (XVI) et (XVII), qui sont des composés modulant la sirtuine et leurs procédés d~utilisation. Les composés modulant la sirtuine peuvent être utilisés pour accroître la durée de vie d~une cellule, et traiter et/ou prévenir une grande variété de maladies et de troubles comprenant, par exemple, des maladies ou des troubles liés au vieillissement ou au stress, au diabète, à l~obésité, aux maladies neurodégénérescentes, à une maladie cardiovasculaire, aux troubles de la coagulation sanguine, à l~inflammation, au cancer et/ou aux bouffées vasomotrices ainsi que des maladies ou des troubles qui tireraient avantage d~une activité mitochondriale accrue. L~invention se rapporte également à des compositions comprenant modulant la sirtuine en combinaison avec un autre agent thérapeutique.

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