C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07K 16/14 (2006.01) C07K 16/16 (2006.01) C07K 16/42 (2006.01) C07K 16/44 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2154487
The present invention provides an immunogenic compound comprising for- mula (I), wherein X is se- lected from the group con- sisting of methyl and hy- drogen; wherein R1 is a suitable functional group of the lysergic ring; wherein R2 is an immunogenic pro- tein; and wherein Y is a bridge to link R1 to R2. The present invention also pro- vides purified monoclonal antibodies specifically reac- tive with the immunogenic compound and reactive with the lysergic ring of ergopeptine and clavine alkaloids. The present invention further provides an antibody which is an anti-idiotype of the monoclonal antibody. Also provided are methods of prevention and treatment of fescue toxicosis utilizing the immunogenic compounds and antibodies of the present invention.
Dawe Donald L.
Hill Nicholas S.
Stuedemann John A.
Thompson Frederick N. Jr.
Gowling Lafleur Henderson Llp
United States Of America Represented By The Secretary Of Agriculture
University Of Georgia Research Foundation Inc.
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