Methods for the treatment of renal cell carcinoma

Details Methods for the treatment of renal cell carcinoma Methods for the treatment of renal cell carcinoma

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/38 (2006.01) C07K 16/40 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2514329

The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma or Wilms tumor.

Compositions et procédés de diagnostic et de traitement de la croissance et de la prolifération de cellules néoplasique chez le mammifères dont l'homme. L'invention se fonde sur l'identification de gènes amplifiés dans le génome des cellules tumorales, par exemple le carcinome de cellules rénales. On s'attend à ce que cette amplification soit associée à une surexpression du produit génique par rapport à l'expression dans les cellules normales du même type de tissu, et qu'elle participe à la tumorigenèse. Par conséquent, les protéines codées par les gènes amplifiés sont supposés être des cibles utiles dans le diagnostic et/ou le traitement (et notamment la prévention) de certains cancers, dont le carcinome de cellules rénales, et peuvent servir de prédicteurs du pronostic d'un traitement de la tumeur. La présente invention concerne de nouveaux procédés de diagnostic et de traitement de tumeurs, par exemple du carcinome de cellules rénales ou de la tumeur de Wilms.

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