A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01)
Patent
CA 2163156
The present invention provides methods for lowering serum cholesterol comprising administering to a mammal in need of treatment a serum cholesterol lowering amount of a compound of formula I or formula II Image I wherein R1 is -H or is a bivalent moiety which distances L from the B-ring by 6-8 intervening atoms; R2 is -H or selected from the group consisting of hydrogen, a straight or branched, saturated or unsaturated chain having 1-5 carbon atoms, a substituted or unsubstituted cycloalkyl group having 5-7 carbon atoms, a bivalent moiety which joins R3 and L to form a 5- to 7-membered heterocyclic ring, and halo-substituted derivatives of the foregoing; R3 is absent or selected from the group consisting of hydrogen, a straight or branched, saturated or unsaturated chain having 1-5 carbon atoms, a substituted or unsubstituted bivalent moiety which joins R2 and L to form a 5- to 7- membered heterocyclic ring, and halo-substituted derivatives of the foregoing; R4 is hydrogen or lower alkyl; R5 and R6 each are independently hydrogen, hydroxy, or a moiety which is converted to hydroxy in vivo; L is -CON< or -N<; and the dotted line in the B-ring is an optional bond; or a pharmaceutically acceptable salt thereof; and optionally, estrogen, for use in lowering serum cholesterol.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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