C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 47/48 (2006.01) C07H 21/02 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2315271
This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF Nucleic Acid Ligand by SELEX methodology and associating the PDGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more PDGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a PDGF Nucleic Acid Ligand or Complex and methods for making the same.
L'invention concerne un procédé de préparation d'un complexe constitué d'un ligand d'acide nucléique PDGF ou d'un composé non immunogène à poids moléculaire élevé ou un composé lipophile. On identifie un ligand d'acide nucléique PDGF par une méthode et on associe le ligand d'acide nucléique PDGF à un composé non immunogène à poids moléculaire élevé ou à un composé lipophile. L'invention concerne en outre des complexes renfermant un ou plusieurs ligands d'acide nucléique PDGF associé(s) à un composé non immunogène à poids moléculaire élevé ou à un composé lipophile. L'invention concerne en outre un produit de synthèse lipidique renfermant un ligand d'acide nucléique PDGF ou un complexe et des procédés d'obtention de ces derniers.
Gold Larry
Janjic Nebojsa
Gilead Sciences Inc.
Mbm Intellectual Property Law Llp
Nexstar Pharmaceuticals Inc.
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