A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/352 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01)
Patent
CA 2382217
A formulation of delta-9-tetrahydrocannabinol in a semi-aqueous solvent, such as 35:10:55 alcohol:water:propylene glycol (v/v), produces a stable clear solution near the solubility point of the drug. Because delta-9- tetrahydrocannabinol has poor affinity for the formulation, it is able to partition out and transport across cell membranes to reach the bloodstream quickly. This has been demonstrated by the comparative tmax values achieved in single dose intravenous and 14 day multiple dose inhalation studies conducted in dogs and rats.
L'invention concerne une formulation de delta-9-tétrahydrocannabinol dans un solvant semi-aqueux, tel que 35:10:55 alcool:eau:propylène glycol (v/v), produisant une solution claire stable située près du point de solubilité du médicament. Présentant une faible affinité pour la formulation, le delta-9-tétrahydrocannabinol peut séparer et transporter des membranes cellulaires afin d'atteindre rapidement la circulation sanguine. Ceci a été démontré par les valeurs comparatives t¿max? obtenues lors d'études réalisées sur des chiens et des rats, comprenant une intraveineuse à dose unique et des inhalations à multiples doses sur 14 jours.
Dedhiya Mahendra G.
Economou Julia J.
Mcphillips Andrea M.
Wynne Beverley Ann
Mccarthy Tetrault Llp
Roxane Laboratories Inc.
Unimed Pharmaceuticals Inc.
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