Hiv p-17 peptide fragment, compositions containing and...

Details Hiv p-17 peptide fragment, compositions containing and... Hiv p-17 peptide fragment, compositions containing and...

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A61K 31/70 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) A61K 48/00 (2006.01) C07K 14/16 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2262432

Peptide fragments of the p17 gag protein of HIV-1 from Clade C of from about 30 to about 50 amino acids, including the region extending from position 75 to position 129, raise antibodies recognizing other subtypes, including Clade A, Clade B, Clade E as well as peptides of non-coextensive but overlapping portions of the p17 gag protein. DNA sequences can be used to encode for the peptides of interest. An example of the Clade C peptide of this invention is a peptide having about 30 to about 32 amino acids taken consecutively from a part or the entirety of the sequence (i) (SEQ ID NO:2), wherein Xaa at position 4 is Tyr; Xaa at position 5 is Cys or Ser; Xaa at position 8 is Lys, Glu, or Ala; Xaa at position 9 is Gly, Lys, Asp, Glu, or Arg; Xaa at position 11 is Glu; Xaa at position 12 is Val; Xaa at position 13 is Arg; Xaa at position 21 is Lys; Xaa at position 22 is Ile; Xaa at position 23 is Glu or Lys; Xaa at position 29 is Ile, Ser or Cys; Xaa at position 33 is a direct bond; and Xaa at position 34 is a direct bond.

Des fragments peptidiques de la protéine gag p17 du VIH-1, obtenus à partir du Clade C possédant environ 30 à environ 50 acides aminés, notamment la région s'étendant entre la position 75 et la position 129, produisent des anticorps reconnaissant d'autres sous-types, notamment Clade A, Clade B, Clade E, de même que des peptides de portions non coextensives mais se chevauchant de la protéine gag p17. On peut utiliser des séquences d'ADN pour coder les peptides d'intérêt. Un exemple du peptide Clade C de l'invention est un peptide possédant environ 30 à environ 32 acides aminés pris consécutivement à partir d'une portion ou de l'intégralité de la séquence suivante (SEQ ID NO:2) (i) dans laquelle Xaa en position 4 est Tyr, en position 5 est Cys ou Ser, en position 8 est Lys, Glu ou Ala, en position 9 est Gly, Lys, Asp, Glu ou Arg, en position 11 est Glu, en position 12 est Val, en position 13 est Arg, en position 21 est Lys, en position 22 est Ile, en position 23 est Glu ou Lys, en position 29 est Ile, Ser ou Cys, et en positions 33 et 34 est une liaison directe.

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