A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 9/127 (2006.01) A61K 31/00 (2006.01) A61K 31/683 (2006.01) A61K 31/685 (2006.01)
Patent
CA 2473490
A composition of matter capable of producing an anti-inflammatory response in vivo in a mammal comprises bodies having a three-dimensional core structure of conformation and size from about 20nm to about 500 m and expressing or expressible on the surface thereof RGDS ligands which will react, optionally in the presence of adapter molecules, with at least one specific receptor wherein the binding of said ligand with said receptors produces an anti- inflammatory response in vivo in said mammal.
L'invention concerne une composition de matière apte à produire une réponse anti-inflammatoire in vivo chez un mammifère comprenant des corps ayant une structure de base tridimensionnelle de conformation et de dimension d'approximativement 20 nm à environ 500 µm, ainsi que des ligands RGDS pouvant exprimer ou être exprimés sur leur surface et qui réagissent, éventuellement en présence de molécules adaptatrices, avec au moins un récepteur spécifique. La liaison dudit ligand avec lesdits récepteurs induit une réponse anti-inflammatoire in vivo chez ledit mammifère.
Bolton Anthony E.
Mandel Arkady
Ridout & Maybee Llp
Vasogen Ireland Limited
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