Prevention and treatment of inflammation and organ injury...

Details Prevention and treatment of inflammation and organ injury... Prevention and treatment of inflammation and organ injury...

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2705541

Provided are methods for preventing and treating inflammation and organ injury after ischemia/reperfusion, and methods for treating lung injury, comprising administering a milk fat globule epidermal growth factor-factor VIII (MFG-E8) to a subject. Also provided are pharmaceutical compositions comprising MFG-E8 in dosage form for preventing and treating inflammation and organ injury after ischemia/reperfusion, and for treating lung injury, and methods of preparing a pharmaceutical composition for preventing and treating inflammation and organ injury after ischemia/reperfusion, and for treating lung injury, comprising formulating MFG-E8 in a pharmaceutical composition.

L'invention concerne des procédés de prévention et de traitement d'inflammation et de lésion d'organe après ischémie/reperfusion et des procédés de traitement d'une lésion pulmonaire, comprenant l'administration à un sujet du facteur de croissance épidermique de globule gras de lait-facteur VIII (MFG-E8). Elle concerne également des compositions pharmaceutiques comprenant MFG-E8 sous forme posologique pour la prévention et le traitement d'inflammation et de lésion d'organe après ischémie/reperfusion, et pour le traitement d'une lésion pulmonaire et des procédés de préparation d'une composition pharmaceutique pour la prévention et le traitement d'inflammation et de lésion d'organe après ischémie/reperfusion et pour le traitement d'une lésion pulmonaire comprenant la formulation de MFG-E8 dans une composition pharmaceutique.

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