A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 31/00 (2006.01) A61K 31/4178 (2006.01) A61K 38/04 (2006.01) A61K 38/08 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2343289
Methods and compositions comprising polyamides capable of binding the minor groove of double-stranded DNA are described for the inhibition or reduction or gene transcription and expression. The polyamides comprise at least four complementary pairs of aromatic carboxamide residues which are selected to specifically contact and/or bind to the nucleotide sequence of a double- stranded DNA target in the promoter region of the target gene. The methods, compositions, and polyamides are disclosed for the inhibition of oncogene transcription and expression as well as the treatment of cancer.
La présente invention concerne des méthodes et des compositions comprenant des polyamides pouvant se lier au sillon mineur d'ADN double brin destinées à inhiber ou à réduire la transcription et l'expression de gène. Ces polyamides comprennent au moins quatre paires de résidus carboxamides aromatiques choisis afin de contacter et/ou de se lier spécifiquement à la séquence de nucléotides d'une cible ADN à double brin dans la région promoteur du gène de la cible. Ces méthodes, compositions et polyamides sont destinés à l'inhibition de la transcription et de l'expression d'oncogène aussi bien qu'au traitement de cancer.
California Institute Of Technology
Smart & Biggar
LandOfFree
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