Novel ezetimibe formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 31/397 (2006.01)

Patent

CA 2738449

Formulations of ezetimibe are described, wherein attention is paid, alternatively or optionally in combination, to (i) the existence of ezetimibe in the form of primary particles, which when blended with a suitable hydrophilic excipient in particulate form are allowed adsorb on the surface of particles of the hydrophilic excipient; (ii) a selection of specific types of excipients; and/ or (iii) a careful control of how the formulation of ezetimibe is obtained.

La présente invention concerne des formules d'ézétimibe, et en particulier, de façon alternative ou éventuellement en combinaison, (i) l'existence de l'ézétimibe sous forme de particules primaires qui, lorsquelles sont mélangées à un excipient hydrophile adapté sous forme particulaire, s'adsorbent à la surface des particules de l'excipient hydrophile; (ii) une sélection de types d'excipient spécifiques; et/ou (iii) une maîtrise poussée de la façon d'obtenir la formule d'ézétimibe.

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