A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01)
Patent
CA 2551560
The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
La présente invention concerne des anticorps, y compris des anticorps polyclonaux et monoclonaux, qui se fixent aux protéines E6 d'au moins trois souches oncogènes du HPV. Globalement, les anticorps se fixent à des motifs d'acides aminés qui sont conservés entre les protéines E6 de différentes souches du HPV et plus particulièrement des souches 16 et 18 du HPV. Ces anticorps peuvent être utilisés pour détecter la protéines E6 du HPV dans un échantillon. Par conséquent, ces anticorps peuvent être utilisés pour des applications diagnostiques, y compris dans des méthodes de diagnostic du cancer. L'invention concerne également des trousses destinées à la mise en oeuvre de ces méthodes, contenant lesdits anticorps.
Belmares Michael P.
Diaz-Sarmiento Chamorro Somoza
Garman Jonathan David
Lu Peter S.
Schweizer Johannes
Arbor Vita Corporation
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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