Methods to identify polynucleotide and polypeptide sequences...

Details Methods to identify polynucleotide and polypeptide sequences... Methods to identify polynucleotide and polypeptide sequences...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2412579

The present invention provides methods for identifying polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a physiological condition, such as disease (including susceptibility (human) or resistance (chimpanzee) to development of AIDS) or enhanced breast development. The methods employ comparison of human and non- human primate sequences using statistical methods. Sequences thus identified may be useful as host therapeutic targets and/or in screening assays.

La présente invention concerne des techniques d'identification de séquences polynucléotidiques et polypeptidiques chez l'homme et/ou chez d'autres primates qui peuvent être associées à une pathologie physiologique, telle qu'une maladie (notamment la susceptibilité (chez l'homme) de développer le sida ou la résistance (chez le chimpanzé) au sida) ou un développement du cancer du sein. Ces techniques comparent des séquences de primates humains et de primates non humains par des méthodes statistiques. Les séquences ainsi identifiées peuvent être utiles comme cibles thérapeutiques hôte et/ou dans des analyses de biodosage.

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