Modulators of p-selectin glycoprotein ligand 1

Details Modulators of p-selectin glycoprotein ligand 1 Modulators of p-selectin glycoprotein ligand 1

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2428822

Compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The compounds and methods of the invention can be used to control unwanted T cell- or NK cell- mediated immune responses in conditions such as autoimmune diseases, transplant rejection, and allergic diseases.

L'invention concerne des composés qui se lient à la Glycoprotéine 1 P-Sélectine (PSGL-1) sur la surface des lymphocytes T ou des cellules NK. Les composés selon l'invention peuvent être utilisés pour induire la déplétion des lymphocytes T ou des cellules NK et/ou induire l'apoptose des lymphocytes T ou des cellules NK. Les composés et les procédés selon l'invention peuvent être utilisés pour réguler les réponses immunitaires à médiation de lymphocytes T ou de cellules NK non désirées dans des affections telles que les maladies auto-immunes, les rejets de greffe et les maladies allergiques.

Affiliated with

Also associated with

Rating

Modulators of p-selectin glycoprotein ligand 1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulators of p-selectin glycoprotein ligand 1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulators of p-selectin glycoprotein ligand 1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1671232