C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01)
Patent
CA 2587084
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
L'invention concerne des méthodes de production d'un agent pathogène avec une valeur d'adaptation réplicative réduite, ainsi que des agents pathogènes atténués produits au moyen de ces méthodes. Dans des exemples spécifiques, la méthode consiste à désoptimiser au moins un codon dans une séquence de codage, ce qui permet de diminuer la valeur d'adaptation réplicative de l'agent pathogène. Cette invention a aussi trait à des méthodes d'utilisation des agents pathogènes atténués en tant que compositions immunogènes.
Burns Cara C.
Campagnoli Raymond
Kew Olen M.
Quay Jacqueline
Shaw Jing
Smart & Biggar
The Government Of The United States Of America As Represented By Centers For Disea
LandOfFree
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