C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/4725 (2006.01) A61K 31/497 (2006.01) A61K 31/502 (2006.01) A61K 31/5377 (2006.01) A61P 5/50 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2747158
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.
L'invention porte sur des nouveaux composés modulant la sirtuine et sur des procédés d'utilisation de ceux-ci. Les composés modulant la sirtuine peuvent être utilisés pour augmenter la durée de vie d'une cellule, et traiter et/ou prévenir une large diversité de maladies et de troubles comprenant, par exemple, des maladies ou troubles liés au vieillissement ou au stress, le diabète, l'obésité, les maladies neurodégénératives, une maladie cardiovasculaire, des troubles de la coagulation du sang, une inflammation, un cancer et/ou les bouffées vasomotrices, ainsi que des maladies ou troubles qui pourraient bénéficier d'une activité mitochondriale accrue. L'invention porte également sur des compositions comprenant un composé modulant la sirtuine en combinaison avec un autre agent thérapeutique.
Gowling Lafleur Henderson Llp
Sirtris Pharmaceuticals Inc.
LandOfFree
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