Microglia facilitated amyloidogenesis assay

Details Microglia facilitated amyloidogenesis assay Microglia facilitated amyloidogenesis assay

G - Physics

01

N

G01N 33/567 (2006.01) A61K 38/00 (2006.01) C12N 9/00 (2006.01) G01N 5/00 (2006.01) G01N 5/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2598492

The present invention describes methods to identify compounds that prevents or treat amyloid accumulation in the brain, as mediated by microglia or cells of macrophage lineage. The present invention further describes compositions containing such compounds, methods of preparing such compositions and methods of using such compositions. The compositions are useful for treating or preventing diseases caused by or associated with cell-mediated amyloid formation, and are particularly useful in treating or preventing neurodegenerative diseases, such as Alzheimer's Disease and bovine spongiform encephalopathy.

La présente invention concerne des procédés permettant d'identifier des composés prévenant ou traitant l'accumulation d'amyloïdes dans l'encéphale, par l'intermédiaire de microglies ou de cellules de la lignée des macrophages. L'invention concerne plus particulièrement des compositions contenant de tels composés, des procédés pour l'élaboration de telles compositions, et des procédés pour l'utilisation de telles compositions. Ces compositions conviennent au traitement ou à la prévention d'affections imputables ou associées à la formation d'amyloïdes de médiation cellulaire, et notamment pour le traitement ou la prévention de maladies neurodégénératives telles que la maladie d'Alzheimer et l'ESB.

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