C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61K 39/155 (2006.01) A61K 39/395 (2006.01) A61P 31/12 (2006.01) C07K 7/04 (2006.01) C07K 14/135 (2006.01) C07K 16/10 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2426312
Compositions and methods are provided for the treatment or prevention of RSV disease by modulating RSV infection and immunity. In particular, amino acid sequences in the RSV G glycoprotein, containing the chemokine motif defined as C-X-X-X-C (or CX3C), are identified that are essential in causing RSV infection and disease. The chemokine motif is biologically active and participates in virus binding to and infection of susceptible cells. The prevention or treatment of RSV infection is achieved by interfering with the motif, such as by administering a vaccine in which the motif is altered or by administration or induction of blocking molecules that inhibit the biological activity of the motif.
L'invention concerne des compositions et des méthodes utilisées dans le traitement ou la prévention de la maladie du RSV par modulation de l'infection et de l'immunité vis-à-vis du RSV. L'invention concerne, en particulier, l'identification de séquences d'acides aminés de la glycoprotéine G du RSV, contenant un motif de chimiokine défini comme C-X-X-X-C (ou CX3C), essentielles dans l'infection et la maladie du RSV. Le motif de chimiokine est biologiquement actif et participe à la liaison du virus et à l'infection des cellules sensibles. La prévention ou le traitement de l'infection du RSV consistent à agir sur le motif, par exemple par administration d'un vaccin dans lequel le motif est altéré ou par administration ou induction de molécules de blocage inhibant l'activité biologique du motif.
Anderson Larry J.
Jones Les
Tripp Ralph A.
Gowling Lafleur Henderson Llp
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
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