Optimization of the molecular properties and formulation of...

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A - Human Necessities

61

K

A61K 38/28 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 31/568 (2006.01) A61K 38/18 (2006.01) A61K 38/27 (2006.01) A61M 11/00 (2006.01)

Patent

CA 2445494

Pegylation or glycosylation of therapeutic proteins to enhance at least one of the solubility, stability and bioavailability thereof, for delivery of an effective amount in an aerosol delivery to the lungs using a minimal number of puffs.

L'invention concerne la pégylation ou la glycosylation de protéines thérapeutiques pour améliorer au moins leur solubilité, leur stabilité et leur biodisponibilité, afin d'en fournir une quantité efficace dans l'administration par aérosol aux poumons pour un nombre minimal de pulvérisations.

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