Imidazoles

Details Imidazoles Imidazoles

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 233/84 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2071498

2071498 9109021 PCTABS00005 Imidazole derivatives of formula (I) wherein A represents methylene or a group -CH2-A'-CH2- wherein A' represents a direct bond, linear alkanediyl, alkenediyl or alkynediyl, hydroxymethylene, or optionally substituted phenylene; R1 and R2 each represents hydrogen, halogen, alkyl, alkoxy, alkylthio, alkylamino, carboxy or alkoxycarbonyl; a and b are 0, 1 or 2; and Het represents a heterocyclic group containing from 5 to 7 ring atoms chosen from carbon, nitrogen, sulphur and oxygen atoms, and salts thereof are inhibitors of acyl coenzyme-A: cholesterol-O-acyl transferase useful for the treatment of conditions such as atherosclerosis, hyperlipidaemia, cholesterol ester storage disease and atheroma in vein grafts.

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