Solubilisation aids for hydrophilic macromolecules

B - Operations – Transporting – 01 – J

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Details

B01J 13/00 (2006.01) A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2207279

The invention provides a process for the preparation of a single phase hydrophobic preparation comprising a hydrophilic species in a hydrophobic solvent wherein a compound which is: (a) a low molecular weight compound having at least some degree of polarity; and/or (b) a lipid-soluble organic acid; and/or (c) a amphiphile; and (d) glycerol or other polyhydric alcohols; is added during the process to aid solubilisation.

La présente invention décrit un procédé pour obtenir une préparation hydrophobe monophasée contenant une espèce hydrophile dans un solvant hydrophobe, à laquelle un composé qui est: (a) un composé de faible poids moléculaire doté d'au moins un certain degré de polarité; et/ou (b) un acide organique liposoluble; et/ou (c) un amphiphile; et (d) du glycérol ou d'autres alcools polyatomiques; est ajouté au cours du processus pour aider à la solubilisation.

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