Aryloxyethylamine derivatives with a combination of partial...

Details Aryloxyethylamine derivatives with a combination of partial... Aryloxyethylamine derivatives with a combination of partial...

A - Human Necessities

61

K

A61K 31/423 (2006.01) A61P 25/00 (2006.01) C07D 263/58 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2587559

The invention relates to a group of novel aryloxyethylamine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): Z-T-Ar wherein: Z is a fragment of the general formula (2): and wherein the other symbols have the meanings given in the specification, and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.

L'invention concerne un groupe de nouveaux dérivés d'aryloxyéthylamine présentant un double mode d'action, à savoir une inhibition du recaptage de la sérotonine et un agonisme partiel des récepteurs de la dopamine-D2. L'invention concerne également l'utilisation d'un desdits composés pour la préparation d'un médicament produisant un effet bénéfique. Les composés de l'invention sont représentés par la formule générale (1) Z-T-Ar, dans laquelle Z est un fragment de formule générale (2), et dans laquelle les autres symboles ont la signification indiquée dans la description, et des tautomères, des stéréoisomères et N-oxydes de ceux-ci, ainsi que des sels, hydrates et solvates acceptables sur le plan pharmacologique desdits composés de formule (1) et leurs tautomères, stéréoisomères et N-oxydes.

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