C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2271783
The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this disclosure, the present invention provides isolated Survivin protein, isolated Survivin encoding nucleic acid molecules, methods of isolating other members of the Survivin family of proteins, methods for identifying agent that blocks Survivin mediated inhibition of cellular apoptosis, methods of using agent that block Survivin mediated inhibition or Survivin expression to modulate biological and pathological processes, and methods of assaying Survivin activity.
La présente invention concerne l'acide aminé d'une protéine inhibant l'apoptose cellulaire, appelée ici protéine Survivine et des molécules d'acide nucléique codant la Survivine. Sur la base de cette divulgation, la présente invention fait état d'une protéine Survivine isolée, de molécules d'acide codant la Survivine isolée, de procédés d'isolement d'autres membres de la famille de protéines Survivine, de procédés d'identification d'agents bloquant l'inhibition, induite par la Survivine, de l'apoptose cellulaire, de procédés d'utilisation d'agents bloquant l'inhibition induite par la Survivine ou l'expression de la Survivine pour moduler des processus biologiques et pathologiques, et de procédés d'évaluation de l'activité de la Survivine.
Deeth Williams Wall Llp
Yale University
LandOfFree
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