Cetp inhibitors and metabolites thereof

Details Cetp inhibitors and metabolites thereof Cetp inhibitors and metabolites thereof

C - Chemistry, Metallurgy

07

D

C07D 215/42 (2006.01)

Patent

CA 2540231

Compounds resulting from the administration of torcetrapib to a mammal, and the use of such compounds as an indicator or biomarker to the presence or exposure of torcetrapib in the plasma of a mammal including humans. The invention is also directed to cholesteryl ester transfer protein (CETP) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein (HDL)-cholesterol and to lower certain other plasma lipid levels, such as low density lipoprotein (LDL)-cholesterol and triglycerides.

L'invention concerne des composés résultant de l'administration de torcétrapibe à un mammifère, et l'utilisation de ces composés comme indicateur ou biomarqueur de la présence ou de la diffusion de torcétrapibe dans le plasma d'un mammifère, notamment l'homme. L'invention concerne également des inhibiteurs de la protéine de transfert d'ester de cholestéryle (CETP), des compositions pharmaceutiques contenant ces inhibiteurs et l'utilisation de ces derniers pour élever certains taux de lipides plasmatiques, notamment le cholestérol à lipoprotéines de haute densité (HDL), et pour abaisser certains autres taux de lipides plasmatiques, par exemple le cholestérol à lipoprotéines de faible densité (LDL) et les triglycérides.

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