Fibronectin binding protein compositions and methods of use

Details Fibronectin binding protein compositions and methods of use Fibronectin binding protein compositions and methods of use

A - Human Necessities

61

K

A61K 39/40 (2006.01) A61K 31/70 (2006.01) A61K 39/085 (2006.01) A61K 39/09 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2277793

Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus aureus, the fnbA and fnbB genes of Streptococcus dysgalactiae, and the sfb gene of Streptococcus pyogenes, and nucleic acid segments encoding these peptides and epitopes. The anti-(fibronectin binding site) antibodies, peptides and epitopes that give rise to antibodies that block the binding of fibronectin binding proteins to fibronectin, and DNA segments encoding these proteins and are of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of streptococcal and staphylococcal colonization in animals or humans. These DNA segments and the peptides derived therefrom are proposed to be of use directly in the preparation of vaccines and also for use as carrier proteins in vaccine formulations.

L'invention porte sur des anticorps qui bloquent la liaison des protéines à la fibronectine, ainsi que sur des épitopes peptidiques tronquées et ayant subi une mutagénèse dirigée issus des gènes fnbA et fnbB de Staphyloccus aureus, les gènes fnbA et fnbB de Streptococcus dysgalactiae et le gène sfb des pyrogènes de Streptococcus, et des segments d'acides nucléiques codant ces peptides et épitopes. Les anticorps de l'anti-(site de liaison de la fibronectine), les peptides et les épitopes qui donnent naissance à des anticorps qui bloquent la liaison des protéines de la fibronectine à la fibronectine, et des segments d'ADN codant ces protéines, et qui sont utilisés dans diverses applications thérapeutiques, diagnostiques et de dépistage, comprennent l'immunisation active et passive et des procédés de prévention de la colonisation streptococcale et staphylococcale chez les animaux et les êtres humains.

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