Quinolone derivatives as dopamine d4 ligands

Details Quinolone derivatives as dopamine d4 ligands Quinolone derivatives as dopamine d4 ligands

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/33 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/66 (2006.01) A61K 31/675 (2006.01) C07D 215/227 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07F 9/547 (2006.01) C07F 9/6558 (2006.01) C07K 14/705 (2006.01) G01N 33/48 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2156409

A class of chemical compounds comprising a 2(1H)-quinolone moiety and a substituted heterocyclic moiety, linked via the 3-position of the 2(1H)-quinolone moiety by a methylene group, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D4 receptor subtype over other dopamine receptor subtypes, and are are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical nueroleptic drugs.

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