A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/34 (2006.01) A61K 9/51 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2703852
Vanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA-containing nanoparticle has a vesicular structure with a polyplex core surrounded by a mixed lipid/PEG- lipid monolayer envelope and offers simple preparation, high loading capacity, and in vivo stability. The nanoparticles have good in vivo stability and a prolonged blood circulation time and can effectively deliver a gene to a biological target such as a tumor.
L'invention porte sur des nanoparticules contenant un acide nucléique et appropriées pour être utilisées comme agents d'administration in vivo pour des acides nucléiques. Les nanoparticules utilisent un conjugué covalent d'un polycation tel que la polyéthylènimine et des phospholipides. La nanoparticule finale contenant de l'ADN a une structure vésiculaire avec un cur polyplexe entouré par une enveloppe monocouche lipide/PEG-lipide mixte et est de préparation simple, à une capacité de charge élevée et une stabilité in vivo. Les nanoparticules ont une bonne stabilité in vivoet un temps prolongé de circulation dans le sang et permettent d'administrer de façon efficace un gène à une cible biologique telle qu'une tumeur.
Kale Amit
Ko Young Tag
Torchilin Vladimir P.
Mbm Intellectual Property Law Llp
Northeastern University
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