Acute leukemia and lymphoblastic lymphoma-specific cd43...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/435 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2607930

The present invention relates to a CD43 epitope expressed on human acute leukemia and lymphoblastic lymphoma cells and its use. More particularly, the present invention relates to a CD43 epitope expressed on human acute leukemia, lymphoblastic lymphoma cells, but not on mature hematopoietic cells, hematopoietic stem cells and non-hematopoietic cells, and to its diagnostic and therapeutic application on acute leukemia and lymphoblastic lymphoma.

La présente invention concerne un déterminant antigénique CD43 exprimé dans les cellules de la leucémie humaine et du lymphosarcome lymphoblastique et son utilisation. Plus particulièrement, la présente invention concerne un déterminant antigénique CD43 exprimé dans la leucémie aiguë humaine, dans les cellules du lymphosarcome lymphoblastique, mais pas dans les cellules hématopoïétiques matures, dans les cellules souches hématopoïétiques et les cellules non hématopoïétiques, et son diagnostic et son application thérapeutique dans la leucémie aiguë et le lymphosarcome lymphoblastique.

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