Selective modulators of peroxisome proliferator activated...

Details Selective modulators of peroxisome proliferator activated... Selective modulators of peroxisome proliferator activated...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/557 (2006.01) A61K 31/5575 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2218955

In accordance with the present invention, there are provided a class of compounds which are capable of selectively modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-.gamma.). The identification of such compounds makes possible the selective intervention in PPAR-.gamma. mediated pathways, without exerting inadvertent effects on pathways mediated by other PPAR isoforms.

Dans le cadre de cette invention, il est présenté une classe de composés capables moduler de manière sélective des processus régulés par un récepteur .gamma. activé de la prolifération des peroxysomes (PPAR-.gamma.). L'identification de ces composés permet d'intervenir de manière sélective dans des voies régulées par PPAR-.gamma. sans entraîner des effets intempestifs sur des voies régulées par d'autres isoformes de PPAR.

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