Methods and compositions for treating asthma,...

Details Methods and compositions for treating asthma,... Methods and compositions for treating asthma,...

A - Human Necessities

61

K

A61K 31/38 (2006.01) A61K 31/381 (2006.01)

Patent

CA 2161978

Methods and compositions are disclosed utilizing optically pure (-)-zileuton for the treatment of asthma, rheumatoid arthritis and ulcerative colitis in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of zileuton. (-)-Zileuton is an inhibitor of 5-lipoxygenase and is therefore useful in the treatment of other conditions related to elevated leukotriene levels. (-)-Zileuton is also an antioxidant and is therefore useful in treating or preventing atherosclerosis.

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