A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 31/19 (2006.01) A61L 15/44 (2006.01)
Patent
CA 2336732
The invention relates to a topical plaster with an active agent in the form of a non-steroidal antirheumatic agent. The plaster consists of a back layer that is inert in relation to the active agent, a self-adhesive matrix layer based on a polyacrylate adhesive, containing the active agent, and a protective film which is removed before use. The invention is characterised in that a) the non-steroidal antirheumatic agent has a free carboxyl group; b) the matrix containing the active agent consists of a polyacrylate adhesive which is cross-linked with multivalent metal ions and which has free carboxyl groups, and is free of hydroxyl groups; c) the matrix contains a fatty acid which serves as a plasticizer and a permeation accelerator; and d) the back layer consists of a material which is elastic in at least one direction.
L'invention concerne un emplâtre topique contenant comme principe actif un agent antirhumatismal non stéroïdien, qui comprend une couche de base inerte par rapport au principe actif, une couche matricielle auto-adhésive à base d'un adhésif polyacrylate et d'une pellicule protectrice à enlever au moment de l'emploi, qui contient le principe actif. L'emplâtre se caractérise en ce que a) l'agent antirhumatismal non stéroïdien dispose d'un groupe carboxyle libre; b) la matrice de l'emplâtre, qui contient le principe actif, comprend un adhésif polyacrylate disposant de groupes carboxyle libres, réticulé avec des ions métal polyvalents et est exempte de groupes hydroxyle; c) la matrice contient comme plastifiant et accélérateur de perméation, un acide gras et d) la couche de base consiste en un matériau, élastique au moins dans un sens.
Blake Cassels & Graydon Llp
Lts Lohmann Therapie-Systeme Ag
LandOfFree
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