Transplantation of neural cells for the treatment of chronic...

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/30 (2006.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2346005

Methods for using neural cells to treat chronic pain and/or spasticity are described. The neural cells can be derived from any mammal, and are preferably human or porcine in origin. The neural cells preferably are serotonergic cells or are gamma-aminobutyric acid (GABA)-producing cells. Neural cells can be obtained from adult, juvenile, embryonic or fetal donors. Neural cells can be modified to be suitable for transplantation into a subject. For example, the neural cells can be modified such that an antigen (e.g., an MHC class I antigen) on the cell surface which is capable of stimulating an immune response against the cell in a subject is altered (e.g., by contact with an anti-MHC class I antibody, or a fragment or derivative thereof) to inhibit rejection of the cell when introduced into the subject or can be genetically modified to produce a factor. In one embodiment, the neural cells are obtained from a pig which is essentially free from organisms or substances which are capable of transmitting infection or disease to the recipient subject. The neural cells of the present invention can be used to treat chronic pain and/or spasticity by delivering the cells into the spinal cord or a subject.

L'invention porte sur des procédés de traitement des douleurs chroniques et des spasmes à l'aide de cellules neurales pouvant provenir de tout mammifère et de préférence d'origine humaine ou porcine, lesdites cellules étant de préférence des cellules sérotonergiques ou des cellules productrices d'acide gamma aminobutyrique (GABA). Les cellules neurales, qui peuvent provenir de donneurs adultes, ou jeunes ou d'embryons ou de foetus, peuvent être modifiées pour les rendre transplantables, par exemple en altérant un antigène de leur surface (par exemple de la classe MHC 1) capable de stimuler une réponse immunitaire contre la cellule chez un patient (par exemple par contact avec un anticorps MHC de classe I ou l'un de ses fragments ou dérivés), afin d'inhiber le rejet de la cellule lors de son introduction dans le patient, ou modifiées génétiquement pour produire un facteur. Dans l'une des exécutions les cellules neurales proviennent d'un porcin absolument exempt d'organismes ou substances pouvant transmettre des infections ou des maladies au patient. Lesdites cellules neurales destinées à traiter la douleur chronique ou les spasmes s'injectent dans la moelle épinière.

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