Use of lipid conjugates in the treatment of diseases...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2761605

This invention provides for the use of compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 2 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond in treating a subject suffering from a disease associated with elevated level of a Matrix Metalloprotease (MMP) such as a malignant cancer.

La présente invention porte sur une utilisation de composés représentés par la structure de la formule générale (A) : dans laquelle L est un lipide ou un phospholipide, Z est soit rien, soit éthanolamine, sérine, inositol, choline ou glycérol, Y est soit rien, soit un groupe espaceur dans une plage de longueur de 2 à 30 atomes, X est un monomère, dimère, oligomère ou polymère physiologiquement acceptable dans lequel X est un glycosaminoglycane ; et n est un nombre de 2 à 1 000, dans lequel toute liaison entre L, Z, Y et X est soit une liaison amide, soit une liaison ester, dans le traitement d'un sujet souffrant d'une maladie associée à un taux élevé de métalloprotéase matrice (MMP), telle qu'un cancer malin.

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