C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 5/0735 (2010.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) C07K 9/00 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2687493
The invention generally relates to the field of recombinant protein production. More particularly, the invention relates to the use of avian embryonic derived stem cell lines, named EBx®, for the production of proteins and more specifically glycoproteins such as antibodies. The invention is useful for the production of monoclonal IgG1 antibody subtype having high cell-mediated cytotoxic activity. The invention relates to the use of such antibodies as a drug to treat cancers and inflammatory diseases.
L'invention concerne généralement le domaine de la production de protéines recombinantes. L'invention se rapporte en particulier à l'utilisation de lignées cellulaires dérivées de cellules souches embryonnaires aviaires, baptisées EBx®, dans la production de protéines et, plus spécifiquement, de glycoprotéines telles que des anticorps. L'invention permet de produire un sous-type d'anticorps monoclonal IgG1 possédant une activité cytotoxique à médiation cellulaire élevée. L'invention porte sur l'utilisation des anticorps précités comme médicaments dans le traitement de cancers et de maladies inflammatoires.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Vivalis
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