C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2744154
Compounds of Formula (I), and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer or inflammation mediated by lipid kinases. Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
L'invention porte sur des composés de la formule I qui comprennent des stéréo-isomères, des isomères géométriques, des tautomères, des solvates, des métabolites et des sels de qualité pharmaceutique de ceux-ci et qui sont utiles pour inhiber des lipides kinases comprenant la p110 alpha et autres isoformes de PI3K, et pour traiter des troubles tels qu'un cancer ou une inflammation à médiation par des lipides kinases. L'invention porte sur des procédés d'utilisation de composés de la formule I pour le diagnostic in vitro, in situ et in vivo, la prévention ou le traitement de tels troubles dans des cellules mammifères, ou des états pathologiques associés.
Chuckowree Irina S.
Dotson Jennafer
Folkes Adrian J.
Heffron Tim
Olivero Alan G.
F.hoffmann-La Roche Ag
Genentech Inc.
Smart & Biggar
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