N-(indolethyl-)cycloamine compounds

Details N-(indolethyl-)cycloamine compounds N-(indolethyl-)cycloamine compounds

C - Chemistry, Metallurgy

07

D

C07D 209/14 (2006.01) A61K 31/404 (2006.01) A61K 31/495 (2006.01) A61P 43/00 (2006.01) C07D 209/18 (2006.01) C07D 209/42 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2510169

The invention relates to n-(indolethyl-)cacloamine compounds of a formula (i), wherein R1, R1 x, Ar and n have a meaning of the claim 1. The inventive compounds consist of inhibitors of serotonin recapture (SSRI) and activators of serotoninenergic receptors 5-HT1A and 5-HT2A. Said compounds are used for preventing and treating various diseases of the central nervous system such as depression, dyskenesia, Parkinson's disease, dementia, vascular cerebral accident, schizophrenia, Alzheimer disease, Lewy bodies dementia, Huntington disease, Gille de la Tourette syndrome, anxiety, learning difficulties, memory disorder, pain, insomnia and neurodegenerative diseases.

L'invention concerne des composés de N-(indoléthyl-)cycloamine de formule (I), dans laquelle R?1'¿, R?1 ¿ X, Ar, et n ont la signification indiquée dans la revendication 1. Ces composés constituent des inhibiteurs de la recapture de la sérotonine (SSRI) ainsi que des effecteurs des récepteurs sérotoninergiques 5-HT¿1A? et 5-HT¿2A?. Ils sont par conséquent appropriés pour la prophylaxie ou le traitement de différentes maladies du système nerveux central, telles que la dépression, la dyskinésie, la maladie de Parkinson, la démence, l'accident vasculaire cérébral, la schizophrénie, la maladie d'Alzheimer, la démence à corps de Lewy, la maladie de Huntington, le syndrome de Gilles de la Tourette, l'angoisse, les troubles de l'apprentissage et de la mémoire, la douleur, les insomnies, ainsi que les maladies neurodégénératives.

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