The use of memantine and brimonidine to attenuate...

Details The use of memantine and brimonidine to attenuate... The use of memantine and brimonidine to attenuate...

A - Human Necessities

61

K

A61K 31/498 (2006.01) A61K 31/13 (2006.01) A61K 31/4164 (2006.01) A61K 31/4168 (2006.01) A61K 31/4709 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2636644

Reducing the VEGF level in a patient suffering from an ocular disease or condition which is characterized by elevated VEGF and/or blood retina barrier (BRB) breakdown which comprises treating said patient with an effective amount of a compound selected from the group consisting of memantine, brimonidine and mixtures thereof.

Cette invention concerne une méthode de réduction du taux de facteur de croissance de l'endothélium vasculaire (VEGF) chez un patient souffrant d'une maladie ou d'un état oculaire se caractérisant par un taux élevé de VEGF et/ou une rupture de la barrière hémato-rétinienne (BRB), laquelle méthode consiste à administrer au patient une quantité efficace d'un composé sélectionné dans le groupe comprenant la mémantine, la brimonidine et des mélanges de ces composés.

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