A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) B01D 9/00 (2006.01) B01F 5/00 (2006.01) B01F 3/08 (2006.01)
Patent
CA 2389908
Novel Apparatus and Process for Preparing Crystalline Particles An apparatus for preparing crystalline particles of a substance suitable for inhalation therapy comprises (i) a first reservoir 3 of said substance dissolved in a liquid solvent;(ii) a second reservoir 3 of liquid antisolvent for said substance which is miscible with the liquid solvent; (iii) a cylindrical mixing chamber 2 having first and second tangential inlet ports and an axial outlet port;(iv) means for delivering the contents of the first and second reservoirs to the mixing chamber in a stream via the first and second inlet ports respectively at independent controlled flow rate, the streams of liquid from the inlet and outlet ports being intimately mixed in the cylindrical mixing chamber through formation of a vortex thereby causing precipitation of crystalline particles of the substance; and (vi) means 5 for collecting crystalline particles suspended in the stream of liquid discharged from the outlet port of the mixing chamber.
L'invention concerne un dispositif de préparation de particules d'une substance convenant à une thérapie par inhalation. Ce dispositif comprend (i) un premier réservoir (3) contenant cette substance dissoute dans un solvant liquide; (ii) un second réservoir (3) contenant un antisolvant liquide de cette substance miscible avec le solvant liquide; (iii) une chambre de mélange cylindrique (2) présentant un premier et un second orifice d'entrée tangentiels et un orifice de sortie axial; (iv) des moyens de distribution du contenu du premier et du second réservoir sous forme de chambre de mélange dans un courant passant par respectivement le premier et le second orifice d'entrée à un débit régulé et indépendant, les courants de liquide provenant des orifices d'entrée et de sortie étant intimement mélangés dans la chambre de mélange cylindrique par la formation d'un tourbillon, provoquant ainsi la précipitation de particules cristallines de la substance; et (vi) des moyens (5) permettant de rassembler les particules cristallines suspendues dans le courant de liquide évacué par l'orifice de sortie de la chambre de mélange.
Ferrie Alan Ronald
Savage Andrew Patrick
Glaxo Group Limited
Gowling Lafleur Henderson Llp
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