C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 519/00 (2006.01) A61K 31/33 (2006.01) A61K 31/425 (2006.01) C07D 477/14 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2264605
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a CH2 group. The naphthosultam is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula (I). Pharmaceutical compositions and methods of use are also included.
L'invention concerne des agents antibactériens de carbapenem, dans lesquels le noyau carbapenem est substitué en position 2 par un naphtosultame lié par un groupe CH¿2?. Le naphtosultame est en outre substitué par divers groupes substituants comprenant au moins un groupe cationique. Les composés de l'invention sont représentés par la formule (I). L'invention concerne également des compositions pharmaceutiques et des méthodes de traitement.
Blizzard Timothy A.
Cama Lovji D.
Ratcliffe Ronald W.
Wilkening Robert R.
Merck & Co. Inc.
Swabey Ogilvy Renault
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